Saturday, April 7, 2018

History of Medicine 1920 to 2000


Penicillin was discovered in 1928 by Scottish scientist Alexander Fleming.  People began using it to treat infections in 1942. 
Starting in World War II, DDT was used as insecticide to combat insect vectors carrying malaria, which was endemic in most tropical regions of the world. The first goal was to protect soldiers, but it was widely adopted as a public health device. In Liberia, for example, the United States had large military operations during the war and the U.S. Public Health Service began the use of DDT for indoor residual spraying (IRS) and as a larvicide, with the goal of controlling malaria in Monrovia, the Liberian capital. In the early 1950s, the project was expanded to nearby villages. In 1953, the World Health Organization (WHO) launched an antimalaria program in parts of Liberia as a pilot project to determine the feasibility of malaria eradication in tropical Africa. However these projects encountered a spate of difficulties that foreshadowed the general retreat from malaria eradication efforts across tropical Africa by the mid-1960s.
Eradication of infectious diseases is an international effort, and several new vaccines have been developed during the post-war years, against infections such as measlesmumps, several strains of influenza and human papilloma virus. The long-known vaccine against Smallpox finally eradicated the disease in the 1970s, and Rinderpest was wiped out in 2011. Eradication of polio is underway. Tissue culture is important for development of vaccines. Though the early success of antiviral vaccines and antibacterial drugs, antiviral drugs were not introduced until the 1970s. Through the WHO, the international community has developed a response protocol against epidemics, displayed during the SARS epidemic in 2003, the Influenza A virus subtype H5N1 from 2004, the Ebola virus epidemic in West Africa and onwards.
As infectious diseases have become less lethal, and the most common causes of death in developed countries are now tumors and cardiovascular diseases, these conditions have received increased attention in medical research.  Cancer treatment had been developed with radiotherapychemotherapy and surgical oncology.
Oral rehydration therapy has been extensively used since the 1970s to treat cholera and other diarrhea-inducing infections.
X-ray imaging was the first kind of medical imaging, and later ultrasonic imagingCT scanningMR scanning and other imaging methods became available.
Genetics have advanced with the discovery of the DNA molecule, genetic mapping and gene therapyStem cell research took off in the 2000s (decade), with stem cell therapy as a promising method.
Evidence-based medicine is a modern concept, not introduced to literature until the 1990s.
Prosthetics have improved. In 1958, Arne Larsson in Sweden became the first patient to depend on an artificial cardiac pacemaker. He died in 2001 at age 86, having outlived its inventor, the surgeon, and 26 pacemakers. Lightweight materials as well as neural prosthetics emerged in the end of the 20th century.
Cardiac surgery was revolutionized in the 1948 as open-heart surgery was introduced for the first time since 1925.
In 1954 Joseph MurrayJ. Hartwell Harrison and others accomplished the first kidney transplantationTransplantations of other organs, such as heart, liver and pancreas, were also introduced during the later 20th century. The first partial face transplant was performed in 2005, and the first full one in 2010. By the end of the 20th century, micro-technology had been used to create tiny robotic devices to assist microsurgery using micro-video and fiber-optic cameras to view internal tissues during surgery with minimally invasive practices.[163]
Laparoscopic surgery was broadly introduced in the 1990s. Natural orifice surgery has followed. Remote surgery is another recent development, with the Lindbergh operation in 2001 as a groundbreaking example.

Comments

The most important improvement in medicine was the development of antibiotics with the discovery of penicillin in 1928 to treat inflammation and infectious diseases. This became available in 1945.

We have yet to see if there are actually cures for the diseases that remain untamed. We are working on eliminating post-op infections and patients seem more open to taking responsibility for our own health. The healthcare industry needs to focus on cost-effective treatments. Medicine continues to function using “trial and error”.

The “bureaucracy” has morphed into the “medical-industrial complex and unlimited government subsidies have made medical treatment costs unsustainable. It will be a challenge to reduce healthcare costs based on supply and demand, but it needs to happen.

The lethal cancer treatments using radiation and chemotherapy have failed in most cases because they destroy our immune systems.

Norb Leahy, Dunwoody GA Tea Party Leader

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